{"id":12306,"date":"2023-11-15T17:21:57","date_gmt":"2023-11-15T16:21:57","guid":{"rendered":"https:\/\/forum.schreiner-group.com\/?p=12306"},"modified":"2023-11-15T17:21:57","modified_gmt":"2023-11-15T16:21:57","slug":"investigational-drug-or-placebo-blinding-with-transparency","status":"publish","type":"post","link":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/","title":{"rendered":"Investigational Drug or Placebo \u2013 Blinding with Transparency"},"content":{"rendered":"<section class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row_content_no_spaces&#8221; content_placement=&#8221;top&#8221; css=&#8221;.vc_custom_1698676509885{margin-top: 150px !important;}&#8221; parallax_background_image=&#8221;12301&#8243;][vc_column][vc_empty_space height=&#8221;615px&#8221;][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1606213327836{background-color: #ffffff !important;}&#8221; el_class=&#8221;article_bighead&#8221;][vc_column][vc_custom_heading text=&#8221;SCHREINER MEDIPHARM&#8221; font_container=&#8221;tag:h2|text_align:center&#8221; use_theme_fonts=&#8221;yes&#8221; el_class=&#8221;topcategory&#8221;][vc_custom_heading text=&#8221;Investigational Drug or Placebo \u2013<br \/>\nBlinding with Transparency&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; use_theme_fonts=&#8221;yes&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<strong>To ensure that clinical trial participants don\u2019t know whether they are receiving the investigational drug or merely a placebo, the substances must be indistinguishable from each other. Schreiner MediPharm has developed a reliable blinding solution for vials used for clinical dosing: due to the use of colored film labels, the different liquids in the vials cannot be distinguished from each other\u2014while the fill level can still be seen.<\/strong>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][vc_column_text]Before a new active pharmaceutical ingredient (API) can be approved for the market, extensive clinical trials are necessary to test its efficacy and safety. They involve comparative studies in which one group of the participants is treated with the new investigational drug, called verum, while a control group receives a placebo. It is crucial that the trial participants do not know which group is being treated with the investigational drug and which group with the placebo to ensure valid testing of the medication\u2019s efficacy.[\/vc_column_text][vc_empty_space height=&#8221;15px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]To ensure no one can tell which is the investigational drug and which is the placebo the two substances must not be visually distinguishable from each other. In the case of liquid APIs in transparent vials that is achieved by colored film labels from Schreiner MediPharm. The pharma expert developed them with WuXi STA. Among other things, the company offers clinical supply services for clinical trials and has been producing investigational drugs for clinical trials since 2008. To reliably blind, i.e., neutralize, its liquid investigational drugs, WuXi STA uses the film solution from Schreiner MediPharm.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_empty_space height=&#8221;15px&#8221;][vc_single_image image=&#8221;12304&#8243; img_size=&#8221;full&#8221; add_caption=&#8221;yes&#8221; onclick=&#8221;link_image&#8221; css_animation=&#8221;fadeIn&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;15px&#8221;][vc_column_text]The blinding solution consists of a self-adhesive label with semi-transparent yellow coloration that was developed precisely for the vials from WuXi STA. The label is transparent enough to see the fill level of the liquid in the vial. The solution from Schreiner MediPharm thus ensures efficient and flexible blinding of the investigational drugs and helps optimize the processes involved in a clinical trial\u2014plus it complies with the requirements of clinical trial regulations.[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text el_class=&#8221;kastenunten&#8221; css=&#8221;.vc_custom_1698676683808{background-color: #f3e294 !important;}&#8221;]<strong>WuXi STA Clinical Supply Services<\/strong><\/p>\n<p>WuXi STA Clinical Supply Services (CSS) can provide rapid, agile and reliable supply support for clinical phase I to IV trials and has been manufacturing clinical investigational drugs since 2008. CSS is embedded into the innovative integrated CMC platform of WuXi STA, can truly realize seamless connection from drug product to clinical supply. The customized solution will fully enable pharmaceutical companies to comparator sourcing, primary packaging, secondary packaging, warehouse storage and cold chain distribution, return and destruction to accelerate the process of clinical supply.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>To ensure that clinical trial participants don\u2019t know whether they are receiving the investigational drug or merely a placebo, the substances must be indistinguishable from each other. Schreiner MediPharm has developed a reliable blinding solution for vials used for clinical dosing: due to the use of colored film labels, the different liquids in the vials cannot be distinguished from each other\u2014while the fill level can still be seen.<\/p>\n","protected":false},"author":2,"featured_media":12304,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[187],"tags":[256],"class_list":["post-12306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-schreiner-medipharm-en","tag-clinical-trials"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum\" \/>\n<meta property=\"og:description\" content=\"To ensure that clinical trial participants don\u2019t know whether they are receiving the investigational drug or merely a placebo, the substances must be indistinguishable from each other. Schreiner MediPharm has developed a reliable blinding solution for vials used for clinical dosing: due to the use of colored film labels, the different liquids in the vials cannot be distinguished from each other\u2014while the fill level can still be seen.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/\" \/>\n<meta property=\"og:site_name\" content=\"Schreiner Group Forum\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-15T16:21:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"markus.liedl@schreiner-group.com\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"markus.liedl@schreiner-group.com\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/\",\"url\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/\",\"name\":\"Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum\",\"isPartOf\":{\"@id\":\"https:\/\/forum.schreiner-group.com\/de\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg\",\"datePublished\":\"2023-11-15T16:21:57+00:00\",\"dateModified\":\"2023-11-15T16:21:57+00:00\",\"author\":{\"@id\":\"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/bd0e2515cfe9118ea30379405cb6f7dc\"},\"breadcrumb\":{\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage\",\"url\":\"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg\",\"contentUrl\":\"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg\",\"width\":1920,\"height\":1280,\"caption\":\"The semi-transparent yellow blinding label prevents verum and placebo from being distinguished in the clinical trial.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\/\/forum.schreiner-group.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Investigational Drug or Placebo \u2013 Blinding with Transparency\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/forum.schreiner-group.com\/de\/#website\",\"url\":\"https:\/\/forum.schreiner-group.com\/de\/\",\"name\":\"Schreiner Group Forum\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/forum.schreiner-group.com\/de\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/bd0e2515cfe9118ea30379405cb6f7dc\",\"name\":\"markus.liedl@schreiner-group.com\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/e83202ed81ba95ae0113c3f2d897918a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/e83202ed81ba95ae0113c3f2d897918a?s=96&d=mm&r=g\",\"caption\":\"markus.liedl@schreiner-group.com\"},\"url\":\"https:\/\/forum.schreiner-group.com\/en\/author\/markus-liedlschreiner-group-de\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/","og_locale":"en_US","og_type":"article","og_title":"Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum","og_description":"To ensure that clinical trial participants don\u2019t know whether they are receiving the investigational drug or merely a placebo, the substances must be indistinguishable from each other. Schreiner MediPharm has developed a reliable blinding solution for vials used for clinical dosing: due to the use of colored film labels, the different liquids in the vials cannot be distinguished from each other\u2014while the fill level can still be seen.","og_url":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/","og_site_name":"Schreiner Group Forum","article_published_time":"2023-11-15T16:21:57+00:00","og_image":[{"width":1920,"height":1280,"url":"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg","type":"image\/jpeg"}],"author":"markus.liedl@schreiner-group.com","twitter_card":"summary_large_image","twitter_misc":{"Written by":"markus.liedl@schreiner-group.com","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/","url":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/","name":"Investigational Drug or Placebo \u2013 Blinding with Transparency - Schreiner Group Forum","isPartOf":{"@id":"https:\/\/forum.schreiner-group.com\/de\/#website"},"primaryImageOfPage":{"@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage"},"image":{"@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage"},"thumbnailUrl":"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg","datePublished":"2023-11-15T16:21:57+00:00","dateModified":"2023-11-15T16:21:57+00:00","author":{"@id":"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/bd0e2515cfe9118ea30379405cb6f7dc"},"breadcrumb":{"@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#primaryimage","url":"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg","contentUrl":"https:\/\/forum.schreiner-group.com\/wp-content\/uploads\/2023\/10\/smp-blinding-transparency.jpg","width":1920,"height":1280,"caption":"The semi-transparent yellow blinding label prevents verum and placebo from being distinguished in the clinical trial."},{"@type":"BreadcrumbList","@id":"https:\/\/forum.schreiner-group.com\/en\/investigational-drug-or-placebo-blinding-with-transparency\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/forum.schreiner-group.com\/en\/"},{"@type":"ListItem","position":2,"name":"Investigational Drug or Placebo \u2013 Blinding with Transparency"}]},{"@type":"WebSite","@id":"https:\/\/forum.schreiner-group.com\/de\/#website","url":"https:\/\/forum.schreiner-group.com\/de\/","name":"Schreiner Group Forum","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/forum.schreiner-group.com\/de\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/bd0e2515cfe9118ea30379405cb6f7dc","name":"markus.liedl@schreiner-group.com","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/forum.schreiner-group.com\/de\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/e83202ed81ba95ae0113c3f2d897918a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e83202ed81ba95ae0113c3f2d897918a?s=96&d=mm&r=g","caption":"markus.liedl@schreiner-group.com"},"url":"https:\/\/forum.schreiner-group.com\/en\/author\/markus-liedlschreiner-group-de\/"}]}},"_links":{"self":[{"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/posts\/12306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/comments?post=12306"}],"version-history":[{"count":8,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/posts\/12306\/revisions"}],"predecessor-version":[{"id":12319,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/posts\/12306\/revisions\/12319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/media\/12304"}],"wp:attachment":[{"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/media?parent=12306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/categories?post=12306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forum.schreiner-group.com\/en\/wp-json\/wp\/v2\/tags?post=12306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}