Innovative active ingredients such as mRNA, biologics, or cell and gene therapies not only bring progress—they also place the highest demands on their packaging. The situation becomes particularly critical when drugs are stored and transported at high sub-zero temperatures. In those cases, reliable tamper evidence truly poses a challenge. Schreiner MediPharm has developed a new solution exactly for that purpose: a transparent deep-freeze seal that reliably works even at temperatures down to -196 °C (-320 °F).

The special feature of the seal is that it will destroy itself when trying to remove it due to a dual security mechanism: the multi-tear effect. It means that not only the seal itself tears due to integrated security cuts that irreversibly destroy it (film tear) but that the cardboard surface of the folding box comes off as well (fiber tear). Any tampering attempt thus becomes immediately visible. In addition, the deep-freeze seal offers a guilloche as an integrated authentication feature. Further overt, semi-covert, and covert authenticity features can be added on request, resulting in a multi-level security solution tailored to the customer’s specific needs.

The transparent deep-freeze seal is suitable for storage temperatures down to -196 °C (-320 °F). Two variants of the seal are available: one for dispensing at 10 °C (50 °F) and a second one for application at temperatures down to as much as -50 °C (-58 °F). Both variants reliably adhere to the folding box across the entire supply chain—from production to final use.

With its many years of expertise in the development of security seals for the pharmaceutical industry, Schreiner MediPharm not only offers technical excellence but also comprehensive consulting support along the entire process chain. Every seal project is customized to suit the specific use case and threat scenario—naturally in compliance with the EU’s Falsified Medicines Directive and ISO 21976.